Francisco X. REAL

Institution Centro Nacional de Investigaciones Oncológicas

Francisco X. Real (Paco) obtained his M.D. from the Universitat Autònoma de Barcelona in 1980 and his Ph.D. in 1986. He trained in Medical Oncology at Memorial Hospital in New York and carried out his doctoral and postdoctoral work in the laboratory of Lloyd J. Old at Memorial Sloan-Kettering Cancer Center. In 1986 he was appointed to the staff of Memorial Hospital. His work focused on the development of immunological strategies for the treatment of melanoma and epithelial cancers. In 1988 he joined the Institut Municipal d’Investigació Mèdica, Barcelona, where he focused on the cell and molecular biology of epithelial cancers. He is Professor of Cell Biology at the Universitat Pompeu Fabra since 2004.
In 2007, he joined the Spanish National Cancer Research Center (CNIO), Madrid. His group has made significant contributions on the molecular mechanisms involved in pancreatic cancer and in pancreatitis and the molecular pathology and epidemiology of bladder and pancreas cancer. His work combines the use of patient samples, cultured cells, and genetically modified mice.
He has published more than 200 original papers and is a member of the Editorial Advisory Board of Gut and Pancreapedia.

Recent selected publications
– Martinelli P et al. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut 2013; 62:1481-1488.
– Flández M et al. Nr5a2 heterozygosity sensitizes to, and cooperates with, inflammation in KRasG12V-driven pancreatic tumorigenesis. Gut 2014; 63:647-655.
– Allory Y et al. TERT promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. Eur Urol 2014; 65:360-366.
– Balbás-Martínez C et al. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet 2013; 45:1464-1469.

Work Group: Patient management (wg4)